She was last seen in the 4800 block of Cypress Creek Avenue in Tuscaloosa, Alabama on July 27, 2007. She was reported driving a Silver Dodge pickup truck with Alabama license plate 63V444G, but the vehicle was found abandoned at a later date. Green was last seen at an apartment on Cypress Avenue. A co-worker said that she had plans to meet a friend at Vieux Carre on Skyland Boulevard to discuss a fundraiser she was planning. She later called her father at 8:20 p.m. to say she was on the way to pick up her son, but she never showed. An off-duty police officer found her 2000 Dodge Ram extended cab pickup in the 4400 block of University Boulevard East on Aug. 4. More than two months after she was reported missing, investigators have released an image showing Lisa Ann Green at a grocery store the night she disappeared including the clothes she was last seen in.
It is uncharacteristic of Green to leave without warning or to be out of touch with her family. She had worked in the telemarketing and recruiting departments at Randall-Reilly Publishing Co. for almost two years prior to her disappearance, and is described as a reliable employee who was never late or absent. She requested vacation time from work shortly before she disappeared; she planned to travel to Panama with her son in August.